References

Methods

BK-S Chung and D-Y Lee (2012). Computational codon optimization of synthetic gene for protein expression. BMC Systems Biology, 6:134, doi:10.1186/1752-0509-6-134 (link)
 
JX Chin, BK-S Chung and D-Y Lee (2014). Codon Optimization On-Line (COOL): a web-based multi-objective optimization platform for synthetic gene design. Bioinformatics, 30 (15): 2210-2212, doi: 10.1093/bioinformatics/btu192 (link)
 

Applications

BK-S Chung, FNK Yusufi, Mariati, YS Yang and D-Y Lee (2013). Enhanced expression of codon optimized interferon gamma in CHO cells. Journal of Biotechnology, Volume 167, Issue 3, Pages 326-333 (link)
 
AM Lanza, KA Curran, LG Rey and HS Alper (2014). A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae. BMC Systems Biology, 8:33, doi:10.1186/1752-0509-8-33 (link)
 
HB Pek, M Klement, KS Ang, BK-S Chung, DSW Ow and D-Y Lee (2015). Exploring codon context bias for designing a synthetic thermostable invertase gene in Escherichia coli. Enzyme and Microbial Technology, 75-76: 57-63. (link)
 
K Yu, KS Ang and D-Y Lee (2017). Chapter 2. Synthetic gene design using codon optimization on-line (COOL). In R. A. Hughes (ed), Synthetic DNA: Methods and Protocols. Springer, New York, pp. 13-33. (link)
 
Ahn J, M-J Jang, KS Ang, H Lee, E-S Choi and D-Y Lee (2016). Codon optimization of Saccharomyces cerevisiae mating factor alpha prepro-leader to improve recombinant protein production in Pichia pastoris. Biotechnology Letters, 38(12): 2137-2143. doi:10.1007/s10529-016-2203-3 (link)
 
KS Ang, S Kyriakopoulos, W Li and D-Y Lee (2016). Multi-omics data driven analysis establishes reference codon biases for synthetic gene design in microbial and mammalian cells. Methods, 102: 26-35. (link)
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